7USJ

BRD4-BD2 in complex with SF2523

Summary for 7USJ

• Entry DOI: 10.2210/pdb7usj/pdb
• Descriptor: Bromodomain-containing protein 4, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one (3 entities in total)
• Functional Keywords: inhibitor, acetyllysine binding pocket, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 26214.56

Authors

Jayasinghe, T.D.,Ronning, D.R. (deposition date: 2022-04-25, release date: 2023-01-18, Last modification date: 2023-10-25)

• Primary citation: Sethi, B.,Kumar, V.,Jayasinghe, T.D.,Dong, Y.,Ronning, D.R.,Zhong, H.A.,Coulter, D.W.,Mahato, R.I.; Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma.; J Control Release, 354:80-90, 2023; PubMed: 36599397; DOI: 10.1016/j.jconrel.2022.12.055

Experimental method

X-RAY DIFFRACTION (2.08 Å)