7UMP

CRYSTAL STRUCTURE OF PHD2 CATALYTIC DOMAIN (CID 7465) IN COMPLEX WITH AKB-6548 AT 1.8 A RESOLUTION

Summary for 7UMP

• Entry DOI: 10.2210/pdb7ump/pdb
• Descriptor: Egl nine homolog 1, FE (II) ION, Vadadustat, ... (5 entities in total)
• Functional Keywords: egln1, phd2, metal binding protein, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 24752.42

Authors

Davie, D.R.,Abendroth, J.,Boyd, J. (deposition date: 2022-04-07, release date: 2022-05-18, Last modification date: 2023-10-25)

• Primary citation: Zuk, A.,Si, Z.,Loi, S.,Bommegowda, S.,Hoivik, D.,Danthi, S.,Molnar, G.,Csizmadia, V.,Rabinowitz, M.; Preclinical Characterization of Vadadustat (AKB-6548), an Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, for the Potential Treatment of Renal Anemia.; J.Pharmacol.Exp.Ther., 383:11-24, 2022; PubMed: 35926869; DOI: 10.1124/jpet.122.001126

Experimental method

X-RAY DIFFRACTION (1.8 Å)