7UM9
Human ALDH1A1 with bound compound CM38
Summary for 7UM9
| Entry DOI | 10.2210/pdb7um9/pdb |
| Descriptor | Retinal dehydrogenase 1, (4-methylfuro[3,2-c]quinolin-2-yl)(piperidin-1-yl)methanone, YTTERBIUM (III) ION, ... (6 entities in total) |
| Functional Keywords | inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 56436.96 |
| Authors | Hurley, T.D. (deposition date: 2022-04-06, release date: 2023-04-26, Last modification date: 2023-11-08) |
| Primary citation | Muralikrishnan, V.,Fang, F.,Given, T.C.,Podicheti, R.,Chtcherbinine, M.,Metcalfe, T.X.,Sriramkumar, S.,O'Hagan, H.M.,Hurley, T.D.,Nephew, K.P. A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers (Basel), 14:-, 2022 Cited by PubMed: 35884498DOI: 10.3390/cancers14143437 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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