7UM9

Human ALDH1A1 with bound compound CM38

7UM9 の概要

• エントリーDOI: 10.2210/pdb7um9/pdb
• 分子名称: Retinal dehydrogenase 1, (4-methylfuro[3,2-c]quinolin-2-yl)(piperidin-1-yl)methanone, YTTERBIUM (III) ION, ... (6 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56436.96

構造登録者

Hurley, T.D. (登録日: 2022-04-06, 公開日: 2023-04-26, 最終更新日: 2023-11-08)

• 主引用文献: Muralikrishnan, V.,Fang, F.,Given, T.C.,Podicheti, R.,Chtcherbinine, M.,Metcalfe, T.X.,Sriramkumar, S.,O'Hagan, H.M.,Hurley, T.D.,Nephew, K.P.; A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer.; Cancers (Basel), 14:-, 2022; PubMed: 35884498; DOI: 10.3390/cancers14143437

実験手法

X-RAY DIFFRACTION (1.8 Å)