7ULU
Human DDAH1 soaked with its inhibitor ClPyrAA
Summary for 7ULU
Entry DOI | 10.2210/pdb7ulu/pdb |
Descriptor | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid (3 entities in total) |
Functional Keywords | ddah1, dimethylargininase, ddah, clpyraa, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 67637.42 |
Authors | Butrin, A.,Zheng, Y.,Tuley, A.,Liu, D.,Fast, W. (deposition date: 2022-04-05, release date: 2023-08-30) |
Primary citation | Tuley, A.,Zheng, Y.,Tommasi, S.,Butrin, A.,May, K.V.,Ahn, Y.,Reidl, T.C.,Weerakoon, L.,Hulin, J.,Meech, R.,Patel, D.S.,Horton, C.P.,Swartzel, C.J.,Kim, Y.,Silverman, B.R.,Mangoni, A.,Liu, D.,Fast, W. Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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