7UJS

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B in complex with ADP

Replaces:  6XDU

Summary for 7UJS

• Entry DOI: 10.2210/pdb7ujs/pdb
• Related: 6x5g
• Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit alpha, Glutamate receptor ionotropic, NMDA 2B, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: camkii, kinase, human, camk2a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33730.43

Authors

Ozden, C.,Santos, N.J.,Stratton, M.M.,Garman, S.C. (deposition date: 2022-03-31, release date: 2022-04-13, Last modification date: 2023-10-18)

• Primary citation: Ozden, C.,Sloutsky, R.,Mitsugi, T.,Santos, N.,Agnello, E.,Gaubitz, C.,Foster, J.,Lapinskas, E.,Esposito, E.A.,Saneyoshi, T.,Kelch, B.A.,Garman, S.C.,Hayashi, Y.,Stratton, M.M.; CaMKII binds both substrates and activators at the active site.; Cell Rep, 40:111064-111064, 2022; PubMed: 35830796; DOI: 10.1016/j.celrep.2022.111064

Experimental method

X-RAY DIFFRACTION (2.75 Å)