7UJ7
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411
Replaces: 6VJ1Summary for 7UJ7
Entry DOI | 10.2210/pdb7uj7/pdb |
Descriptor | Estrogen receptor, 11alpha-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1(10),2,4-triene-3,17beta-diol (3 entities in total) |
Functional Keywords | estrogen receptor, hormone, serm, ru39411, activating mutations, y537s, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 122331.14 |
Authors | Fanning, S.W.,Greene, G.L. (deposition date: 2022-03-30, release date: 2022-05-04, Last modification date: 2023-10-18) |
Primary citation | Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W. Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11:-, 2022 Cited by PubMed: 35575456DOI: 10.7554/eLife.72512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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