7UJ4

Inhibition of Human Menin by SNDX-5613

7UJ4 の概要

• エントリーDOI: 10.2210/pdb7uj4/pdb
• 分子名称: Isoform 2 of Menin, 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: human menin, transcription, inhibitor complex, sndx-5613
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110893.21

構造登録者

McKeever, B.M.,Kulkarni, S.,McGeehan, G.M. (登録日: 2022-03-30, 公開日: 2022-12-14, 最終更新日: 2023-10-25)

• 主引用文献: Perner, F.,Stein, E.M.,Wenge, D.V.,Singh, S.,Kim, J.,Apazidis, A.,Rahnamoun, H.,Anand, D.,Marinaccio, C.,Hatton, C.,Wen, Y.,Stone, R.M.,Schaller, D.,Mowla, S.,Xiao, W.,Gamlen, H.A.,Stonestrom, A.J.,Persaud, S.,Ener, E.,Cutler, J.A.,Doench, J.G.,McGeehan, G.M.,Volkamer, A.,Chodera, J.D.,Nowak, R.P.,Fischer, E.S.,Levine, R.L.,Armstrong, S.A.,Cai, S.F.; MEN1 mutations mediate clinical resistance to menin inhibition.; Nature, 615:913-919, 2023; PubMed: 36922589; DOI: 10.1038/s41586-023-05755-9

実験手法

X-RAY DIFFRACTION (1.96 Å)