7UGK

Crystal structure of the human queuine salvage enzyme DUF2419, wild-type apo form

Summary for 7UGK

• Entry DOI: 10.2210/pdb7ugk/pdb
• Related: 7U07
• Descriptor: Queuosine salvage protein DUF2419, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
• Functional Keywords: 7-deazaguanine salvage, queuosine, trna modification, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 79142.03

Authors

Hung, S.-H.,Swairjo, M.A. (deposition date: 2022-03-24, release date: 2022-12-21, Last modification date: 2023-10-25)

• Primary citation: Hung, S.H.,Elliott, G.I.,Ramkumar, T.R.,Burtnyak, L.,McGrenaghan, C.J.,Alkuzweny, S.,Quaiyum, S.,Iwata-Reuyl, D.,Pan, X.,Green, B.D.,Kelly, V.P.,de Crecy-Lagard, V.,Swairjo, M.A.; Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.; Nucleic Acids Res., 51:935-951, 2023; PubMed: 36610787; DOI: 10.1093/nar/gkac1231

Experimental method

X-RAY DIFFRACTION (1.78 Å)