7UGG

Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine

Summary for 7UGG

• Entry DOI: 10.2210/pdb7ugg/pdb
• EMDB information: 26488
• Descriptor: Transient receptor potential cation channel subfamily V member 3, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, ... (5 entities in total)
• Functional Keywords: transient receptor potential v family member 3, trp, channel, closed, trpv3, anesthetic, dyclonine, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 389740.02

Authors

Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2022-03-24, release date: 2022-06-08, Last modification date: 2024-02-14)

• Primary citation: Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I.; Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.; Nat Commun, 13:2795-2795, 2022; PubMed: 35589741; DOI: 10.1038/s41467-022-30537-8

Experimental method

ELECTRON MICROSCOPY (3.16 Å)