7UGF
First bromodomain of BRD4 liganded with BMS-536924
Summary for 7UGF
Entry DOI | 10.2210/pdb7ugf/pdb |
Descriptor | Bromodomain-containing protein 4, (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, small molecule ligand, complex, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15889.68 |
Authors | Schonbrunn, E.,Bikowitz, M. (deposition date: 2022-03-24, release date: 2023-04-12, Last modification date: 2023-10-25) |
Primary citation | Schonbrunn, E.,Bikowitz, M. Structural basis of CBP and EP300 interaction with kinase inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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