7UFV

Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766

7UFV の概要

• エントリーDOI: 10.2210/pdb7ufv/pdb
• 分子名称: DDB1- and CUL4-associated factor 1, (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: wd-repeat, wdr, dcaf1, sgc, structural genomics, structural genomics consortium, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72346.31

構造登録者

Kimani, S.,Li, A.,Li, Y.,Dong, A.,Hutchinson, A.,Seitova, A.,Wilson, B.,Al-Awar, R.,Vedadi, M.,Brown, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (登録日: 2022-03-23, 公開日: 2022-05-04, 最終更新日: 2024-04-03)

• 主引用文献: Li, A.S.M.,Kimani, S.,Wilson, B.,Noureldin, M.,Gonzalez-Alvarez, H.,Mamai, A.,Hoffer, L.,Guilinger, J.P.,Zhang, Y.,von Rechenberg, M.,Disch, J.S.,Mulhern, C.J.,Slakman, B.L.,Cuozzo, J.W.,Dong, A.,Poda, G.,Mohammed, M.,Saraon, P.,Mittal, M.,Modh, P.,Rathod, V.,Patel, B.,Ackloo, S.,Santhakumar, V.,Szewczyk, M.M.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Marcellus, R.,Guie, M.A.,Keefe, A.D.,Brown, P.J.,Halabelian, L.,Al-Awar, R.,Vedadi, M.; Discovery of Nanomolar DCAF1 Small Molecule Ligands.; J.Med.Chem., 66:5041-5060, 2023; PubMed: 36948210; DOI: 10.1021/acs.jmedchem.2c02132

実験手法

X-RAY DIFFRACTION (1.9 Å)