7UF9
CYP3A4 bound to an inhibitor
Summary for 7UF9
| Entry DOI | 10.2210/pdb7uf9/pdb |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2R)-1-oxo-3-phenyl-1-{[2-(pyridin-4-yl)ethyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate (3 entities in total) |
| Functional Keywords | cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 56894.00 |
| Authors | Sevrioukova, I. (deposition date: 2022-03-22, release date: 2022-07-27, Last modification date: 2023-10-18) |
| Primary citation | Samuels, E.R.,Sevrioukova, I.F. Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35806297DOI: 10.3390/ijms23137291 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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