7UE3

PANK3 complex structure with compound PZ-3804

Summary for 7UE3

Entry DOI	10.2210/pdb7ue3/pdb
Descriptor	Pantothenate kinase 3, 6-[4-({4-[(2R)-1-hydroxypropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
Functional Keywords	pank, substrate, complex, transferase, pantothenate kinase, inhibitor, activator
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43986.66
Authors	White, S.W.,Yun, M.,Lee, R.E. (deposition date: 2022-03-21, release date: 2023-03-29, Last modification date: 2024-10-09)
Primary citation	Tangallapally, R.,Subramanian, C.,Yun, M.K.,Edwards, A.,Sharma, L.K.,Yang, L.,Creed, K.,Wang, J.,Jackowski, S.,Rock, C.O.,White, S.W.,Lee, R.E. Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67:14432-14442, 2024 Cited by PubMed: 39136313 DOI: 10.1021/acs.jmedchem.4c01211 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation