7UD7

Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom

7UD7 の概要

• エントリーDOI: 10.2210/pdb7ud7/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: hemoglobin, sickle cell disease, antisickling, no release, oxygen equilibrium, oxygen transport
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65390.12

構造登録者

Donkor, A.K.,Musayev, F.N.,Safo, M.K. (登録日: 2022-03-18, 公開日: 2022-03-30, 最終更新日: 2023-10-18)

• 主引用文献: Alhashimi, R.T.,Ghatge, M.S.,Donkor, A.K.,Deshpande, T.M.,Anabaraonye, N.,Alramadhani, D.,Danso-Danquah, R.,Huang, B.,Zhang, Y.,Musayev, F.N.,Abdulmalik, O.,Safo, M.K.; Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease.; Biomolecules, 12:-, 2022; PubMed: 35625623; DOI: 10.3390/biom12050696

実験手法

X-RAY DIFFRACTION (1.8 Å)