7UCF
Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24
7UCF の概要
エントリーDOI | 10.2210/pdb7ucf/pdb |
分子名称 | Envelope glycoprotein gp41, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (22 entities in total) |
機能のキーワード | broadly neutralizing antibody, bnab, hiv-1, cd4 binding site, vh1-2, vrc01-class, antiviral protein, viral protein-immune system complex, viral protein/immune system |
由来する生物種 | Human immunodeficiency virus 1 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 183583.37 |
構造登録者 | |
主引用文献 | Barnes, C.O.,Schoofs, T.,Gnanapragasam, P.N.P.,Golijanin, J.,Huey-Tubman, K.E.,Gruell, H.,Schommers, P.,Suh-Toma, N.,Lee, Y.E.,Cetrulo Lorenzi, J.C.,Piechocka-Trocha, A.,Scheid, J.F.,West Jr., A.P.,Walker, B.D.,Seaman, M.S.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J. A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8:eabp8155-eabp8155, 2022 Cited by PubMed: 35960796DOI: 10.1126/sciadv.abp8155 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (4 Å) |
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