7UC7

Stat5a Core in complex with Compound 17

7UC7 の概要

• エントリーDOI: 10.2210/pdb7uc7/pdb
• 分子名称: Signal transducer and activator of transcription 5A, GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, ... (4 entities in total)
• 機能のキーワード: stat5a, activator, transcription, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66653.56

構造登録者

Meagher, J.L.,Stuckey, J.A. (登録日: 2022-03-16, 公開日: 2023-02-15, 最終更新日: 2024-04-03)

• 主引用文献: Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Kirchhoff, P.D.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S.; Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.; J.Med.Chem., 66:2717-2743, 2023; PubMed: 36735833; DOI: 10.1021/acs.jmedchem.2c01665

実験手法

X-RAY DIFFRACTION (3.102 Å)