7U8C

Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex

This is a non-PDB format compatible entry.

Summary for 7U8C

• Entry DOI: 10.2210/pdb7u8c/pdb
• Descriptor: Mesothelin, cleaved form, MORab 15B6 Fab heavy chain, MORab 15B6 Fab light chain, ... (4 entities in total)
• Functional Keywords: mesothelin, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 47526.91

Authors

Zhan, J.,Esser, L.,Xia, D. (deposition date: 2022-03-08, release date: 2022-06-08, Last modification date: 2024-11-06)

Primary citation

Liu, X.,Onda, M.,Watson, N.,Hassan, R.,Ho, M.,Bera, T.K.,Wei, J.,Chakraborty, A.,Beers, R.,Zhou, Q.,Shajahan, A.,Azadi, P.,Zhan, J.,Xia, D.,Pastan, I.
Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.
Proc.Natl.Acad.Sci.USA, 119:e2202439119-e2202439119, 2022

PubMed Abstract: SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.

PubMed: 35512094
DOI: 10.1073/pnas.2202439119

Experimental method

X-RAY DIFFRACTION (1.74 Å)