7U6M

Albumin binding domain fused to a mutant of the Erwinia asparaginase

Summary for 7U6M

Entry DOI	10.2210/pdb7u6m/pdb
Descriptor	L-asparaginase, ASPARTIC ACID (3 entities in total)
Functional Keywords	asparaginase, albumin binding domain, hydrolase
Biological source	Dickeya chrysanthemi
Total number of polymer chains	4
Total formula weight	150900.24
Authors	Lavie, A.,Nguyen, H.A. (deposition date: 2022-03-04, release date: 2022-08-31, Last modification date: 2023-10-25)
Primary citation	Van Trimpont, M.,Schalk, A.M.,De Visser, Y.,Nguyen, H.A.,Reunes, L.,Vandemeulebroecke, K.,Peeters, E.,Su, Y.,Lee, H.,Lorenzi, P.L.,Chan, W.K.,Mondelaers, V.,De Moerloose, B.,Lammens, T.,Goossens, S.,Van Vlierberghe, P.,Lavie, A. In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia. Haematologica, 108:409-419, 2023 Cited by PubMed: 35979719 DOI: 10.3324/haematol.2022.281390 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation