7U6M
Albumin binding domain fused to a mutant of the Erwinia asparaginase
Summary for 7U6M
Entry DOI | 10.2210/pdb7u6m/pdb |
Descriptor | L-asparaginase, ASPARTIC ACID (3 entities in total) |
Functional Keywords | asparaginase, albumin binding domain, hydrolase |
Biological source | Dickeya chrysanthemi |
Total number of polymer chains | 4 |
Total formula weight | 150900.24 |
Authors | Lavie, A.,Nguyen, H.A. (deposition date: 2022-03-04, release date: 2022-08-31, Last modification date: 2023-10-25) |
Primary citation | Van Trimpont, M.,Schalk, A.M.,De Visser, Y.,Nguyen, H.A.,Reunes, L.,Vandemeulebroecke, K.,Peeters, E.,Su, Y.,Lee, H.,Lorenzi, P.L.,Chan, W.K.,Mondelaers, V.,De Moerloose, B.,Lammens, T.,Goossens, S.,Van Vlierberghe, P.,Lavie, A. In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia. Haematologica, 108:409-419, 2023 Cited by PubMed: 35979719DOI: 10.3324/haematol.2022.281390 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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