7U6A

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 3-thienylmethyl Benzhydroxamic Acid Inhibitor

Summary for 7U6A

Entry DOI	10.2210/pdb7u6a/pdb
Descriptor	Polyamine deacetylase HDAC10, N-hydroxy-4-({[(thiophen-3-yl)methyl]amino}methyl)benzamide, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	histone deacetylase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	1
Total formula weight	75808.55
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2022-03-03, release date: 2022-04-06, Last modification date: 2023-10-18)
Primary citation	Zeyen, P.,Zeyn, Y.,Herp, D.,Mahmoudi, F.,Yesiloglu, T.Z.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Ridinger, J.,Herbst-Gervasoni, C.J.,Christianson, D.W.,Oehme, I.,Jung, M.,Kramer, O.H.,Sippl, W. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234:114272-114272, 2022 Cited by PubMed: 35306288 DOI: 10.1016/j.ejmech.2022.114272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation