7U69
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Phenethyl Piperidine-4-acrylhydroxamic Acid Inhibitor
Summary for 7U69
Entry DOI | 10.2210/pdb7u69/pdb |
Descriptor | Polyamine deacetylase HDAC10, (2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 75758.52 |
Authors | Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2022-03-03, release date: 2022-04-06, Last modification date: 2023-10-18) |
Primary citation | Zeyen, P.,Zeyn, Y.,Herp, D.,Mahmoudi, F.,Yesiloglu, T.Z.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Ridinger, J.,Herbst-Gervasoni, C.J.,Christianson, D.W.,Oehme, I.,Jung, M.,Kramer, O.H.,Sippl, W. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234:114272-114272, 2022 Cited by PubMed: 35306288DOI: 10.1016/j.ejmech.2022.114272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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