7U59

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Piperidine-4-hydroxamic acid Inhibitor

Summary for 7U59

Entry DOI	10.2210/pdb7u59/pdb
Descriptor	Polyamine deacetylase HDAC10, 1,2-ETHANEDIOL, 1-[2-(benzylamino)ethyl]-N-hydroxypiperidine-4-carboxamide, ... (8 entities in total)
Functional Keywords	histone deacetylase, hydrolase
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	1
Total formula weight	75983.71
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2022-03-01, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citation	Herp, D.,Ridinger, J.,Robaa, D.,Shinsky, S.A.,Schmidtkunz, K.,Yesiloglu, T.Z.,Bayer, T.,Steimbach, R.R.,Herbst-Gervasoni, C.J.,Merz, A.,Romier, C.,Sehr, P.,Gunkel, N.,Miller, A.K.,Christianson, D.W.,Oehme, I.,Sippl, W.,Jung, M. First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem, 23:e202200180-e202200180, 2022 Cited by PubMed: 35608330 DOI: 10.1002/cbic.202200180 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation