7U3Y

[L233] Self-assembling tensegrity triangle with two turns, three turns and three turns of DNA per axis by linker addition with P1 symmetry

7U3Y の概要

• エントリーDOI: 10.2210/pdb7u3y/pdb
• 関連するPDBエントリー: 3GBI
• 分子名称: DNA (5'-D(*CP*AP*CP*GP*AP*GP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*TP*AP*TP*GP*CP*TP*A)-3'), DNA (5'-D(*CP*TP*TP*AP*GP*CP*AP*TP*AP*G)-3'), ... (11 entities in total)
• 機能のキーワード: tensegrity triangle, self-assembling crystal, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 11
• 化学式量合計: 50796.07

構造登録者

Woloszyn, K.,Vecchioni, S.,Seeman, N.C.,Sha, R.,Ohayon, Y.P. (登録日: 2022-02-28, 公開日: 2022-09-28, 最終更新日: 2023-10-25)

主引用文献

Woloszyn, K.,Vecchioni, S.,Ohayon, Y.P.,Lu, B.,Ma, Y.,Huang, Q.,Zhu, E.,Chernovolenko, D.,Markus, T.,Jonoska, N.,Mao, C.,Seeman, N.C.,Sha, R.
Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants.
Adv Mater, 34:e2206876-e2206876, 2022

PubMed Abstract: The DNA tensegrity triangle is known to reliably self-assemble into a 3D rhombohedral crystalline lattice via sticky-end cohesion. Here, the library of accessible motifs is expanded through covalent extensions of intertriangle regions and sticky-end-coordinated linkages of adjacent triangles with double helical segments using both geometrically symmetric and asymmetric configurations. The molecular structures of 18 self-assembled architectures at resolutions of 3.32-9.32 Å are reported; the observed cell dimensions, cavity sizes, and cross-sectional areas agree with theoretical expectations. These data demonstrate that fine control over triclinic and rhombohedral crystal parameters and the customizability of more complex 3D DNA lattices are attainable via rational design. It is anticipated that augmented DNA architectures may be fine-tuned for the self-assembly of designer nanocages, guest-host complexes, and proscriptive 3D nanomaterials, as originally envisioned. Finally, designer asymmetric crystalline building blocks can be seen as a first step toward controlling and encoding information in three dimensions.

PubMed: 36100349
DOI: 10.1002/adma.202206876

実験手法

X-RAY DIFFRACTION (6.06 Å)