7U1O

Crystal structure of queuine salvage enzyme DUF2419 complexed with queuosine

Summary for 7U1O

• Entry DOI: 10.2210/pdb7u1o/pdb
• Related: 7U07
• Descriptor: Queuine salvage enzyme DUF2419, 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-beta-D-ribofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, MALONATE ION, ... (5 entities in total)
• Functional Keywords: 7-deazaguanine salvage, queuosine, trna modification, hydrolase
• Biological source: Sphaerobacter thermophilus DSM 20745
• Total number of polymer chains: 2
• Total formula weight: 75506.38

Authors

Hung, S.-H.,Swairjo, M.A. (deposition date: 2022-02-21, release date: 2022-12-21, Last modification date: 2023-10-25)

• Primary citation: Hung, S.H.,Elliott, G.I.,Ramkumar, T.R.,Burtnyak, L.,McGrenaghan, C.J.,Alkuzweny, S.,Quaiyum, S.,Iwata-Reuyl, D.,Pan, X.,Green, B.D.,Kelly, V.P.,de Crecy-Lagard, V.,Swairjo, M.A.; Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.; Nucleic Acids Res., 51:935-951, 2023; PubMed: 36610787; DOI: 10.1093/nar/gkac1231

Experimental method

X-RAY DIFFRACTION (2.35 Å)