7TYT

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the down conformation

7TYT の概要

• エントリーDOI: 10.2210/pdb7tyt/pdb
• EMDBエントリー: 20528 26194
• 分子名称: ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: katp channel, sur1, kir6.2, repaglinide, rpg, sulfonylurea receptor, potassium transport, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 365221.38

構造登録者

Shyng, S.L.,Sung, M.W.,Driggers, C.M. (登録日: 2022-02-14, 公開日: 2022-08-31, 最終更新日: 2022-09-14)

• 主引用文献: Sung, M.W.,Driggers, C.M.,Mostofian, B.,Russo, J.D.,Patton, B.L.,Zuckerman, D.M.,Shyng, S.L.; Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.; J.Mol.Biol., 434:167789-167789, 2022; PubMed: 35964676; DOI: 10.1016/j.jmb.2022.167789

実験手法

ELECTRON MICROSCOPY (3.6 Å)