7TYM
Cryo-EM Structure of insulin receptor-related receptor (IRR) in active-state captured at pH 9. The 3D refinement was applied with C2 symmetry
Summary for 7TYM
Entry DOI | 10.2210/pdb7tym/pdb |
EMDB information | 26181 26183 26185 |
Descriptor | Insulin receptor-related protein (1 entity in total) |
Functional Keywords | receptor tyrosine kinase, insulin receptor family, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 287759.09 |
Authors | Wang, L.W.,Hall, C.,Li, J.,Choi, E.,Bai, X.C. (deposition date: 2022-02-13, release date: 2023-02-15, Last modification date: 2023-05-31) |
Primary citation | Wang, L.,Hall, C.,Li, J.,Choi, E.,Bai, X.C. Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30:661-669, 2023 Cited by PubMed: 37055497DOI: 10.1038/s41594-023-00974-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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