7TY3

Crystal Structure of SETD2 Bound to an Indole-based Inhibitor

7TY3 の概要

• エントリーDOI: 10.2210/pdb7ty3/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYLMETHIONINE, ... (6 entities in total)
• 機能のキーワード: histone-lysine n-methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33012.71

構造登録者

Farrow, N.A. (登録日: 2022-02-11, 公開日: 2022-08-31, 最終更新日: 2024-04-03)

• 主引用文献: Alford, J.S.,Lampe, J.W.,Brach, D.,Chesworth, R.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Kutok, J.L.,Raimondi, A.,Riera, T.V.,Shook, B.,Tang, C.,Totman, J.,Farrow, N.A.; Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.; Acs Med.Chem.Lett., 13:1137-1143, 2022; PubMed: 35859865; DOI: 10.1021/acsmedchemlett.2c00167

実験手法

X-RAY DIFFRACTION (2.3 Å)