7TVJ

Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex

Summary for 7TVJ

• Entry DOI: 10.2210/pdb7tvj/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, Mb(SHP2PTP_13), CITRATE ANION, ... (4 entities in total)
• Functional Keywords: monobody, shp2, phosphatase, complex, inhibitor, signaling, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 91160.31

Authors

Sha, F.,Koide, S. (deposition date: 2022-02-05, release date: 2023-02-15, Last modification date: 2023-10-25)

• Primary citation: Sha, F.,Kurosawa, K.,Glasser, E.,Ketavarapu, G.,Albazzaz, S.,Koide, A.,Koide, S.; Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.; J.Mol.Biol., 435:168010-168010, 2023; PubMed: 36806475; DOI: 10.1016/j.jmb.2023.168010

Experimental method

X-RAY DIFFRACTION (2.39 Å)