7TUS

Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation

7TUS の概要

• エントリーDOI: 10.2210/pdb7tus/pdb
• 分子名称: Antibody Heavy Chain, Antibody Light Chain, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: antibody therapeutics, antibody-drug conjugate, catalytic antibody, protein modification, engineered cysteine, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 192963.24

構造登録者

Park, H.,Rader, C. (登録日: 2022-02-03, 公開日: 2022-06-08, 最終更新日: 2023-10-18)

• 主引用文献: Hwang, D.,Nilchan, N.,Park, H.,Roy, R.N.,Roush, W.R.,Rader, C.; Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.; Bioconjug.Chem., 33:1192-1200, 2022; PubMed: 35584359; DOI: 10.1021/acs.bioconjchem.2c00146

実験手法

X-RAY DIFFRACTION (2.4 Å)