7TTI

Human KCC1 bound with VU0463271 In an outward-open state

7TTI の概要

• エントリーDOI: 10.2210/pdb7tti/pdb
• EMDBエントリー: 26115 26116
• 分子名称: Solute carrier family 12 member 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide (3 entities in total)
• 機能のキーワード: slc12a4, vu0463271, outward-open state, transport protein-inhibitor complex, transport protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 244003.59

構造登録者

Zhao, Y.X.,Cao, E.H. (登録日: 2022-02-01, 公開日: 2022-06-29, 最終更新日: 2022-07-13)

• 主引用文献: Zhao, Y.,Shen, J.,Wang, Q.,Ruiz Munevar, M.J.,Vidossich, P.,De Vivo, M.,Zhou, M.,Cao, E.; Structure of the human cation-chloride cotransport KCC1 in an outward-open state.; Proc.Natl.Acad.Sci.USA, 119:e2109083119-e2109083119, 2022; PubMed: 35759661; DOI: 10.1073/pnas.2109083119

実験手法

ELECTRON MICROSCOPY (3.5 Å)