7TT8

Human LRH-1 LBD bound to agonist 6N-10CA and fragment of Tif2 coactivator

Summary for 7TT8

• Entry DOI: 10.2210/pdb7tt8/pdb
• Descriptor: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), ... (4 entities in total)
• Functional Keywords: lrh-1, nuclear receptor, ligand, synthetic agonist, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 30661.45

Authors

Cato, M.L.,Ortlund, E.A. (deposition date: 2022-01-31, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Cato, M.L.,Cornelison, J.L.,Spurlin, R.M.,Courouble, V.V.,Patel, A.B.,Flynn, A.R.,Johnson, A.M.,Okafor, C.D.,Frank, F.,D'Agostino, E.H.,Griffin, P.R.,Jui, N.T.,Ortlund, E.A.; Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.; J.Med.Chem., 65:6888-6902, 2022; PubMed: 35503419; DOI: 10.1021/acs.jmedchem.2c00235

Experimental method

X-RAY DIFFRACTION (2.8 Å)