7TT8
Human LRH-1 LBD bound to agonist 6N-10CA and fragment of Tif2 coactivator
Summary for 7TT8
Entry DOI | 10.2210/pdb7tt8/pdb |
Descriptor | Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), ... (4 entities in total) |
Functional Keywords | lrh-1, nuclear receptor, ligand, synthetic agonist, nuclear protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 30661.45 |
Authors | Cato, M.L.,Ortlund, E.A. (deposition date: 2022-01-31, release date: 2022-05-11, Last modification date: 2023-10-18) |
Primary citation | Cato, M.L.,Cornelison, J.L.,Spurlin, R.M.,Courouble, V.V.,Patel, A.B.,Flynn, A.R.,Johnson, A.M.,Okafor, C.D.,Frank, F.,D'Agostino, E.H.,Griffin, P.R.,Jui, N.T.,Ortlund, E.A. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. J.Med.Chem., 65:6888-6902, 2022 Cited by PubMed: 35503419DOI: 10.1021/acs.jmedchem.2c00235 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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