7TSF
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(4,4-difluoropiperidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine
Summary for 7TSF
| Entry DOI | 10.2210/pdb7tsf/pdb |
| Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
| Functional Keywords | nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase |
| Biological source | Rattus norvegicus (Norway rat) |
| Total number of polymer chains | 2 |
| Total formula weight | 100054.62 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2022-01-31, release date: 2022-07-13, Last modification date: 2023-10-18) |
| Primary citation | Vasu, D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Bioorg.Med.Chem., 69:116878-116878, 2022 Cited by PubMed: 35772285DOI: 10.1016/j.bmc.2022.116878 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.776 Å) |
Structure validation
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