7TS0

Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein

Summary for 7TS0

• Entry DOI: 10.2210/pdb7ts0/pdb
• EMDB information: 26103 26104
• Descriptor: Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Urocortin, Dominant negative Go alpha subunit, ... (6 entities in total)
• Functional Keywords: gpcr, corticotropin releasing factor receptor 2, urocortin 1, go protein, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 186297.20

Authors

Zhao, L.-H.,Lin, J.,Mao, C.,Zhou, X.E.,Ji, S.,Shen, D.,Xiao, P.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E. (deposition date: 2022-01-31, release date: 2022-11-09, Last modification date: 2022-11-16)

• Primary citation: Zhao, L.H.,Lin, J.,Ji, S.Y.,Zhou, X.E.,Mao, C.,Shen, D.D.,He, X.,Xiao, P.,Sun, J.,Melcher, K.,Zhang, Y.,Yu, X.,Xu, H.E.; Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.; Nat Commun, 13:6670-6670, 2022; PubMed: 36335102; DOI: 10.1038/s41467-022-33851-3

Experimental method

ELECTRON MICROSCOPY (2.8 Å)