7TRJ
The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit
Summary for 7TRJ
| Entry DOI | 10.2210/pdb7trj/pdb |
| EMDB information | 26098 |
| Descriptor | Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... (5 entities in total) |
| Functional Keywords | translation, integrated stress response |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 10 |
| Total formula weight | 522363.29 |
| Authors | Wang, L.,Schoof, M.,Lawrence, R.,Boone, M.,Frost, A.,Walter, P. (deposition date: 2022-01-29, release date: 2022-04-27, Last modification date: 2024-02-21) |
| Primary citation | Boone, M.,Wang, L.,Lawrence, R.,Frost, A.,Walter, P.,Schoof, M. A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. Elife, 11:-, 2022 Cited by PubMed: 35416150DOI: 10.7554/eLife.76171 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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