7TPS

Crystal structure of ALPN-202 (engineered CD80 vIgD) in complex with PD-L1

Summary for 7TPS

• Entry DOI: 10.2210/pdb7tps/pdb
• Descriptor: T-lymphocyte activation antigen CD80, Programmed cell death 1 ligand 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: co-stimulatory, ig-like, v-type, t-cell, proliferation, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 76208.22

Authors

Demonte, D.W.,Maurer, M.F.,Akutsu, M.,Kimbung, Y.R.,Logan, D.T.,Walse, B. (deposition date: 2022-01-26, release date: 2022-03-16, Last modification date: 2023-10-18)

• Primary citation: Maurer, M.F.,Lewis, K.E.,Kuijper, J.L.,Ardourel, D.,Gudgeon, C.J.,Chandrasekaran, S.,Mudri, S.L.,Kleist, K.N.,Navas, C.,Wolfson, M.F.,Rixon, M.W.,Swanson, R.,Dillon, S.R.,Levin, S.D.,Kimbung, Y.R.,Akutsu, M.,Logan, D.T.,Walse, B.,Swiderek, K.M.,Peng, S.L.; The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.; Nat Commun, 13:1790-1790, 2022; PubMed: 35379805; DOI: 10.1038/s41467-022-29286-5

Experimental method

X-RAY DIFFRACTION (3.15 Å)