7TP4

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22

7TP4 の概要

• エントリーDOI: 10.2210/pdb7tp4/pdb
• 分子名称: Spike protein S1, K398.22 heavy chain, K398.22 light chain, ... (6 entities in total)
• 機能のキーワード: sars-cov-2, antibody, neutralizing antibody, fab, covid-19, coronavirus, receptor-binding domain, rbd, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70418.44

構造登録者

Yuan, M.,Zhu, X.,Wilson, I.A. (登録日: 2022-01-24, 公開日: 2022-02-23, 最終更新日: 2023-10-18)

• 主引用文献: He, W.T.,Yuan, M.,Callaghan, S.,Musharrafieh, R.,Song, G.,Silva, M.,Beutler, N.,Lee, W.H.,Yong, P.,Torres, J.L.,Melo, M.,Zhou, P.,Zhao, F.,Zhu, X.,Peng, L.,Huang, D.,Anzanello, F.,Ricketts, J.,Parren, M.,Garcia, E.,Ferguson, M.,Rinaldi, W.,Rawlings, S.A.,Nemazee, D.,Smith, D.M.,Briney, B.,Safonova, Y.,Rogers, T.F.,Dan, J.M.,Zhang, Z.,Weiskopf, D.,Sette, A.,Crotty, S.,Irvine, D.J.,Ward, A.B.,Wilson, I.A.,Burton, D.R.,Andrabi, R.; Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.; Sci Transl Med, 14:eabl9605-eabl9605, 2022; PubMed: 35947674; DOI: 10.1126/scitranslmed.abl9605

実験手法

X-RAY DIFFRACTION (1.95 Å)