7TJO
HIV-1 gp120 complex with CJF-II-197-S
Summary for 7TJO
Entry DOI | 10.2210/pdb7tjo/pdb |
Descriptor | Glycoprotein 120, N~1~-[(1R,2R)-5-{[(3R)-3-aminopyrrolidin-1-yl]methyl}-2-(carbamimidamidomethyl)-2,3-dihydro-1H-inden-1-yl]-N~2~-(4-chloro-3-fluorophenyl)ethanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | hiv gp120 entry inhibitor structure-based drug design x-ray crystallography antibody-dependent cellular cytotoxicity, virus |
Biological source | HIV-1 06TG.HT008 |
Total number of polymer chains | 4 |
Total formula weight | 169063.16 |
Authors | Gong, Z.,Hendrickson, W.A. (deposition date: 2022-01-16, release date: 2023-01-25, Last modification date: 2023-10-25) |
Primary citation | Chaplain, C.,Fritschi, C.J.,Anang, S.,Gong, Z.,Richard, J.,Bourassa, C.,Liang, S.,Mohammadi, M.,Park, J.,Finzi, A.,Madani, N.,Sodroski, J.G.,Abrams, C.F.,Hendrickson, W.A.,Smith, A.B. Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines ACS Medicinal Chemistry Letters, 14:51-58, 2023 Cited by DOI: 10.1021/acsmedchemlett.2c00376PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.07 Å) |
Structure validation
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