7TJO

HIV-1 gp120 complex with CJF-II-197-S

7TJO の概要

• エントリーDOI: 10.2210/pdb7tjo/pdb
• 分子名称: Glycoprotein 120, N~1~-[(1R,2R)-5-{[(3R)-3-aminopyrrolidin-1-yl]methyl}-2-(carbamimidamidomethyl)-2,3-dihydro-1H-inden-1-yl]-N~2~-(4-chloro-3-fluorophenyl)ethanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: hiv gp120 entry inhibitor structure-based drug design x-ray crystallography antibody-dependent cellular cytotoxicity, virus
• 由来する生物種: HIV-1 06TG.HT008
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169063.16

構造登録者

Gong, Z.,Hendrickson, W.A. (登録日: 2022-01-16, 公開日: 2023-01-25, 最終更新日: 2023-10-25)

• 主引用文献: Chaplain, C.,Fritschi, C.J.,Anang, S.,Gong, Z.,Richard, J.,Bourassa, C.,Liang, S.,Mohammadi, M.,Park, J.,Finzi, A.,Madani, N.,Sodroski, J.G.,Abrams, C.F.,Hendrickson, W.A.,Smith, A.B.; Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines; ACS Medicinal Chemistry Letters, 14:51-58, 2023; DOI: 10.1021/acsmedchemlett.2c00376

実験手法

X-RAY DIFFRACTION (3.07 Å)