7TIN

The Structure of S. aureus MenD

7TIN の概要

• エントリーDOI: 10.2210/pdb7tin/pdb
• 分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, THIAMINE DIPHOSPHATE, GLYCINE, ... (7 entities in total)
• 機能のキーワード: menaquinone biosynthesis, mend, sephchc synthase, transferase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 255674.59

構造登録者

Johnston, J.M.,Stanborough, T.,Ho, N.A.T.,Akazong, E.W.,Jiao, W. (登録日: 2022-01-14, 公開日: 2022-09-14, 最終更新日: 2023-10-25)

• 主引用文献: Stanborough, T.,Ho, N.A.T.,Bulloch, E.M.M.,Bashiri, G.,Dawes, S.S.,Akazong, E.W.,Titterington, J.,Allison, T.M.,Jiao, W.,Johnston, J.M.; Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway.; Philos.Trans.R.Soc.Lond.B Biol.Sci., 378:20220035-20220035, 2023; PubMed: 36633276; DOI: 10.1098/rstb.2022.0035

実験手法

X-RAY DIFFRACTION (2.35 Å)