7THS

Macrocyclic plasmin inhibitor

7THS の概要

• エントリーDOI: 10.2210/pdb7ths/pdb
• 分子名称: Plasminogen, (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protease, inhibitor, blood clotting, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57019.34

構造登録者

Guojie, W. (登録日: 2022-01-12, 公開日: 2023-01-18, 最終更新日: 2023-10-25)

• 主引用文献: Wiedemeyer, S.J.A.,Wu, G.,Pham, T.L.P.,Lang-Henkel, H.,Perez Urzua, B.,Whisstock, J.C.,Law, R.H.P.,Steinmetzer, T.; Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.; Chemmedchem, 18:e202200632-e202200632, 2023; PubMed: 36710259; DOI: 10.1002/cmdc.202200632

実験手法

X-RAY DIFFRACTION (1.8 Å)