7TH7
Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor B23
Summary for 7TH7
Entry DOI | 10.2210/pdb7th7/pdb |
Related | 7TGS 7TGT 7TGU 7TGV 7TH1 7TH6 |
Descriptor | Peptidyl-prolyl cis-trans isomerase F, mitochondrial, 3-(4'-{[(4S,7S,11R,19S)-19-{[2-(2-aminoethoxy)ethyl]carbamoyl}-7-benzyl-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18,19,20,21,22-icosahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosin-4-yl]methyl}[1,1'-biphenyl]-4-yl)propanoic acid (3 entities in total) |
Functional Keywords | oxidative stress, necrosis, mitochondrial permeability, isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18525.17 |
Authors | Rangwala, A.M.,Thakur, M.K.,Seeliger, M.A.,Peterson, A.A.,Liu, D.R. (deposition date: 2022-01-10, release date: 2022-08-24, Last modification date: 2023-10-18) |
Primary citation | Peterson, A.A.,Rangwala, A.M.,Thakur, M.K.,Ward, P.S.,Hung, C.,Outhwaite, I.R.,Chan, A.I.,Usanov, D.L.,Mootha, V.K.,Seeliger, M.A.,Liu, D.R. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat.Chem.Biol., 18:1184-1195, 2022 Cited by PubMed: 36163383DOI: 10.1038/s41589-022-01116-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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