7TGR

Structure of SARS-CoV-2 main protease in complex with GC376

Summary for 7TGR

• Entry DOI: 10.2210/pdb7tgr/pdb
• Related PRD ID: PRD_002495
• Descriptor: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (8 entities in total)
• Functional Keywords: protease, inhibitor, complex, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34716.41

Authors

Esler, M.A.,Shi, K.,Aihara, H.,Harris, R.S. (deposition date: 2022-01-09, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Moghadasi, S.A.,Esler, M.A.,Otsuka, Y.,Becker, J.T.,Moraes, S.N.,Anderson, C.B.,Chamakuri, S.,Belica, C.,Wick, C.,Harki, D.A.,Young, D.W.,Scampavia, L.,Spicer, T.P.,Shi, K.,Aihara, H.,Brown, W.L.,Harris, R.S.; Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M pro /3CL pro in Living Cells.; Mbio, 13:e0078422-e0078422, 2022; PubMed: 35471084; DOI: 10.1128/mbio.00784-22

Experimental method

X-RAY DIFFRACTION (1.68 Å)