7TGM

Crystal structure of HSC-AMS bound DesD, the desferrioxamine synthetase from the Streptomyces griseoflavus ferrimycin biosynthetic pathway

7TGM の概要

• エントリーDOI: 10.2210/pdb7tgm/pdb
• 分子名称: Desferrioxamine synthetase DesD, GLYCEROL, 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid, ... (8 entities in total)
• 機能のキーワード: nrps-independent siderophore (nis) synthetase, iterative synthetase, amide ligase, adenylate-forming enzyme, ligase, inhibitor, ligase-inhibitor complex, ligase/inhibitor
• 由来する生物種: Streptomyces griseoflavus
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 357175.32

構造登録者

Patel, K.D.,Gulick, A.M. (登録日: 2022-01-07, 公開日: 2022-07-06, 最終更新日: 2023-10-18)

• 主引用文献: Yang, J.,Banas, V.S.,Patel, K.D.,Rivera, G.S.M.,Mydy, L.S.,Gulick, A.M.,Wencewicz, T.A.; An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD.; J.Biol.Chem., 298:102166-102166, 2022; PubMed: 35750210; DOI: 10.1016/j.jbc.2022.102166

実験手法

X-RAY DIFFRACTION (2.5 Å)