7TEV
Human Ornithine Aminotransferase cocrystallized with its inhibitor, (3S,4R)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylate
7TEV の概要
エントリーDOI | 10.2210/pdb7tev/pdb |
分子名称 | Ornithine aminotransferase, mitochondrial, (1S,3R,4S)-3-formyl-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopentane-1-carboxylic acid (3 entities in total) |
機能のキーワード | human ornithine aminotransferase, hoat, oat, mechanism-based inhibitor, mbi, irreversible inhibitor, inactivator, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 135745.89 |
構造登録者 | |
主引用文献 | Zhu, W.,Butrin, A.,Melani, R.D.,Doubleday, P.F.,Ferreira, G.M.,Tavares, M.T.,Habeeb Mohammad, T.S.,Beaupre, B.A.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. J.Am.Chem.Soc., 144:5629-5642, 2022 Cited by PubMed: 35293728DOI: 10.1021/jacs.2c00924 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.91 Å) |
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