7TEU

Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1

7TEU の概要

• エントリーDOI: 10.2210/pdb7teu/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: jak2, tyrosine kinase, inhibitor, cytokine signaling, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37788.09

構造登録者

Hubbard, S.R. (登録日: 2022-01-05, 公開日: 2023-06-21, 最終更新日: 2023-10-25)

• 主引用文献: Arwood, M.L.,Liu, Y.,Harkins, S.K.,Weinstock, D.M.,Yang, L.,Stevenson, K.E.,Plana, O.D.,Dong, J.,Cirka, H.,Jones, K.L.,Virtanen, A.T.,Gupta, D.G.,Ceas, A.,Lawney, B.,Yoda, A.,Leahy, C.,Hao, M.,He, Z.,Choi, H.G.,Wang, Y.,Silvennoinen, O.,Hubbard, S.R.,Zhang, T.,Gray, N.S.,Li, L.S.; New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.; Cell Chem Biol, 30:618-, 2023; PubMed: 37290440; DOI: 10.1016/j.chembiol.2023.05.007

実験手法

X-RAY DIFFRACTION (1.45 Å)