7TD8

Integrin alaphIIBbeta3 complex with Tirofiban

Summary for 7TD8

• Entry DOI: 10.2210/pdb7td8/pdb
• Related: 7TCT
• Descriptor: Integrin alpha-IIb, SULFATE ION, MAGNESIUM ION, ... (13 entities in total)
• Functional Keywords: complex, inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 300871.24

Authors

Zhu, J.,Lin, F.-Y.,Zhu, J.,Springer, T.A. (deposition date: 2021-12-30, release date: 2022-08-17, Last modification date: 2023-10-25)

• Primary citation: Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A.; A general chemical principle for creating closure-stabilizing integrin inhibitors.; Cell, 185:3533-3550.e27, 2022; PubMed: 36113427; DOI: 10.1016/j.cell.2022.08.008

Experimental method

X-RAY DIFFRACTION (2.6 Å)