7TCZ

Human cytomegalovirus protease mutant (C84A, C87A, C138A, C202A) in complex with inhibitor

7TCZ の概要

• エントリーDOI: 10.2210/pdb7tcz/pdb
• 分子名称: Assemblin, [1-(2-oxopropyl)-4-phenyl-1H-1,2,3-triazol-5-yl]methyl benzylcarbamate (3 entities in total)
• 機能のキーワード: protease, viral protein, hyrdrolase-hydrolase inhibitor complex, hyrdrolase/hydrolase inhibitor
• 由来する生物種: Human betaherpesvirus 5
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29325.81

構造登録者

Hulce, K.R.,Bohn, M.,Ongpipattanakul, C.,Jaishankar, P.,Renslo, A.R.,Craik, C.S. (登録日: 2021-12-29, 公開日: 2022-01-12, 最終更新日: 2023-10-18)

• 主引用文献: Hulce, K.R.,Jaishankar, P.,Lee, G.M.,Bohn, M.F.,Connelly, E.J.,Wucherer, K.,Ongpipattanakul, C.,Volk, R.F.,Chuo, S.W.,Arkin, M.R.,Renslo, A.R.,Craik, C.S.; Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.; Cell Chem Biol, 29:785-798.e19, 2022; PubMed: 35364007; DOI: 10.1016/j.chembiol.2022.03.007

実験手法

X-RAY DIFFRACTION (2.67 Å)