7TBC
Crystal structure of Plasmepsin X from Plasmodium falciparum in complex with WM382
Summary for 7TBC
Entry DOI | 10.2210/pdb7tbc/pdb |
Descriptor | Plasmepsin 10, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | aspartyl protease, hydrolase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 1 |
Total formula weight | 44799.60 |
Authors | Christensen, J.B.,Hodder, A.N.,Scally, S.W.,Cowman, A.F. (deposition date: 2021-12-21, release date: 2022-05-04, Last modification date: 2023-10-18) |
Primary citation | Hodder, A.N.,Christensen, J.,Scally, S.,Triglia, T.,Ngo, A.,Birkinshaw, R.W.,Bailey, B.,Favuzza, P.,Dietrich, M.H.,Tham, W.H.,Czabotar, P.E.,Lowes, K.,Guo, Z.,Murgolo, N.,Lera Ruiz, M.,McCauley, J.A.,Sleebs, B.E.,Olsen, D.,Cowman, A.F. Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30:947-, 2022 Cited by PubMed: 35460613DOI: 10.1016/j.str.2022.03.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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