7T9U

Crystal structure of hSTING with an agonist (SHR169224)

7T9U の概要

• エントリーDOI: 10.2210/pdb7t9u/pdb
• 分子名称: Stimulator of interferon genes protein, CALCIUM ION, (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, ... (4 entities in total)
• 機能のキーワード: immune system, immune system-inhibitor complex, immune system-agonist complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23037.87

構造登録者

Chowdhury, R.,Miller, M. (登録日: 2021-12-20, 公開日: 2022-12-21, 最終更新日: 2023-10-25)

• 主引用文献: Song, C.,Liu, D.,Liu, S.,Li, D.,Horecny, I.,Zhang, X.,Li, P.,Chen, L.,Miller, M.,Chowdhury, R.,Issa, M.,Shen, R.,Yan, Y.,Zhang, F.,Zhang, L.,Zhang, L.,Bai, C.,Feng, J.,Zhuang, L.,Zhang, R.,Li, J.,Wilkinson, H.,Liu, J.,Tao, W.; SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.; Sci Rep, 12:8579-8579, 2022; PubMed: 35595822; DOI: 10.1038/s41598-022-12449-1

実験手法

X-RAY DIFFRACTION (2.46 Å)